About Plenhyage XL line
Plenhyage XL line offers advanced injectable gels designed for professional aesthetic use. These polynucleotide-based therapies are CE marked Class III medical devices, aiming to improve skin quality and regeneration. Bioformula s.r.l., based in Italy, specializes in regenerative aesthetic medicine products using high-purity polynucleotides derived from salmon DNA.

Give your skin a healthy glow everyone
Plenhyage XL Strong is a premium 2 ml pre-filled syringe containing 2.5% high-molecular-weight polynucleotides (≈25 mg/ml), often complemented with hyaluronic acid. This injectable gel is engineered for deeper skin regeneration and revitalization in cases of pronounced aging, scarring, photo-damage, or tissue laxity.
Key Features
Plenhyage XL Strong features a high-concentration polynucleotide gel at 2.5%, making it ideal for treating moderate to severe skin aging, sagging, wrinkles, scarring, and other skin imperfections. The formulation is fully biocompatible and absorbable, derived from purified salmon DNA, minimizing the risk of immunological reactions. As a CE certified Class III medical device, it ensures safety and efficacy for aesthetic professionals. Its mechanism of action includes stimulating fibroblast proliferation, neocollagenesis, elastin production, and microcirculation, while offering intensive hydration and antioxidant protection through free radical scavenging. Designed for application on areas such as the face, neck, décolleté, arms, thighs, and knees, the product delivers visible improvements that typically last from 6 to 12 months following a personalized induction protocol of 2–4 sessions, with maintenance treatments recommended every 6–12 months.
About Bioformula s.r.l.
Bioformula excels in polynucleotide-based injectables that support tissue repair, cellular renewal, and hydration. With Plenhyage XL, the brand offers medium and strong formulations—Strong being the 2.5% concentration—ready for medical professionals worldwide. The company provides clinical training, treatment protocols, and ensures compliance with regulations via CE certification.