Product
Overview
Radiesse
is a biocompatible, collagen-stimulating dermal filler engineered to deliver
both immediate correction and durable skin quality improvement. Its unique
formulation—calcium hydroxylapatite (CaHA) microspheres embedded in a smooth
aqueous gel—provides instant lift while initiating a sustained biological
response that promotes neocollagenesis. The result is natural-looking contour,
improved elasticity and firmness, and visible textural refinement that can last
up to 12–18 months, depending on treatment area and individual factors.
Composition & Technology
Radiesse contains CaHA microspheres (typically 25–45 μm) suspended in a carrier gel composed of water, glycerin, and sodium carboxymethylcellulose. The gel delivers immediate volumization and uniform placement, while the spherical CaHA particles function as a three-dimensional scaffold that recruits fibroblasts and supports new collagen deposition. Over time, the gel is resorbed; the CaHA matrix is gradually metabolized into calcium and phosphate ions as newly synthesized collagen replaces the initial volume support.
Mechanism of Action
Immediately
after injection, the viscoelastic gel restores volume and softens folds,
enhancing contour in areas such as the midface, jawline, and dorsal hands. In
the subsequent weeks and months, the CaHA scaffold stimulates fibroblast
activity and extracellular matrix remodeling. This controlled biostimulatory
phase yields progressive thickening of the dermis, improved skin density, and a
smoother surface profile. As the CaHA microspheres biodegrade, the newly formed
collagen network maintains a natural, durable result without the feel of a
persistent implant.
Indications & Treatment Areas
Radiesse
is indicated for the correction of moderate to severe facial wrinkles and
folds, including nasolabial folds, and is widely used for structural support in
cheeks and chin, mandibular angle and jawline definition, and temple or midface
volume restoration when clinically appropriate. In addition, Radiesse is an
established option for rejuvenation of the dorsum of the hands, where it
replenishes volume, camouflages prominent veins and tendons, and improves the
perception of skin quality. Patient selection, facial assessment, and a
holistic treatment plan remain essential to achieving balanced, natural
outcomes.
Clinical Performance & Longevity
Clinical experience and published evidence support Radiesse’s dual benefit: immediate contouring with a natural, soft feel and a biostimulatory phase that enhances firmness and texture over time. Longevity commonly ranges from 12 to 18 months in facial applications, with variation by anatomical site, injection depth, product volume, and patient metabolism. In the hands, durable improvements are also observed, with high patient satisfaction tied to the subtle, progressive nature of the result.
Technique Considerations
Radiesse
can be placed with needle or cannula, using linear threading, fanning, or depot
techniques according to the anatomical plane and treatment objective. Depth of
placement typically ranges from deep dermis to supraperiosteal levels for
structural support, while more superficial planes require cautious techniques
to avoid visibility or irregularities. For contouring, precise vectoring and
conservative volumes help maintain natural proportions. Adhering to aseptic
technique, slow injection with low extrusion pressure, and frequent aspiration
or dynamic needle repositioning protocols are standard risk-reduction practices
in vascular-rich zones.
Safety, Biocompatibility & Tolerability
CaHA
is a long-used, biocompatible biomaterial in medical devices, and Radiesse is
fully biodegradable. The most common post-treatment events are mild and
transient—erythema, edema, tenderness, or bruising at the injection site. As
with all injectable procedures, proper anatomical knowledge and complication
management readiness are mandatory. Practitioners should follow evidence-based
protocols for vascular safety, product placement, and aftercare, and provide
patients with clear guidance on expected recovery and when to seek follow-up.
Contraindications & Precautions
Radiesse
should not be used in patients with known hypersensitivity to any component,
active infection or inflammation in the treatment area, or in individuals with
a history of severe allergies or anaphylaxis without appropriate evaluation. It
is not indicated for lip augmentation or periorbital intradermal use. Caution
is advised in patients with bleeding disorders, those on anticoagulants, and in
high-risk vascular territories. Pregnancy and lactation are generally
considered exclusions in line with standard aesthetic-medicine practice.
Formats, Handling & Storage
Radiesse
is supplied in prefilled syringes in multiple configurations, including a
lidocaine-containing option where available, to enhance injection comfort.
Store at controlled room temperature according to the manufacturer’s
instructions. Do not freeze. Use appropriate needle or cannula gauges
recommended for the target plane and indication and follow lot traceability and
disposal protocols consistent with clinic quality systems.
Summary
Radiesse
integrates immediate volumizing performance with proven biostimulatory activity
to deliver natural contour and progressive skin quality gains. Its CaHA-based
scaffold induces new collagen formation as the carrier gel and microspheres are
safely resorbed, supporting results that look and feel authentic. For clinics
focused on regenerative outcomes and patient demand for longevity with
low-maintenance follow-up, Radiesse is a cornerstone injectable across facial
sculpting and hand rejuvenation.