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aesPlla® — Next-Generation Poly-L-Lactic Acid Biostimulator

About aesPlla®

aesPlla® is an innovative injectable biostimulator based on poly-L-lactic acid (PLLA), developed to restore lost facial volume, improve skin laxity, and stimulate natural collagen production. Positioned within the regenerative aesthetics market, aesPlla® offers a reliable, long-lasting, and gradual skin rejuvenation solution by harnessing the power of biostimulation — encouraging the body’s own collagen regeneration processes for natural, harmonious results.

This product belongs to the new wave of collagen biostimulators offering subtle, progressive, and customizable treatments for facial aging, volumization, and skin quality enhancement.

What is aesPlla®?

aesPlla® is a PLLA-based injectable filler designed for deep dermal administration. Unlike hyaluronic acid fillers, which provide immediate volumizing by occupying space, PLLA products like aesPlla® work by stimulating fibroblasts to produce new collagen over time. The microparticles of PLLA gradually biodegrade, leaving behind a denser, firmer dermal matrix that improves skin elasticity, thickness, and contour.


This product is primarily used for:

  • Facial volumization and contour restoration
  • Treatment of wrinkles and folds
  • Correction of skin laxity
  • General skin rejuvenation and firmness improvement

 

How Does aesPlla® Work?

Once injected into the dermis or subcutaneous layer, aesPlla®’s poly-L-lactic acid microparticles act as a scaffold that induces a controlled inflammatory response, recruiting fibroblasts to the site of injection. These cells, in turn, produce new collagen (Type I and III) over the following weeks and months, gradually restoring skin thickness, elasticity, and volume.

 

The biostimulation process continues for several months after treatment, with visible improvements in:

  • Facial volume
  • Skin firmness
  • Wrinkle reduction
  • Overall skin texture and density

 

Unlike immediate fillers, the effects of aesPlla® are progressive and long-lasting, typically visible after 4-6 weeks and enduring for up to 2 years.

 

Product Advantages

  • Gradual, natural-looking results
  • Long-lasting collagen production
  • Safe, biocompatible, and biodegradable PLLA microparticles
  • Excellent profile for full-face volumization and skin rejuvenation
  • Minimal risk of hypersensitivity or severe adverse reactions

 

Indications & Treatment Areas

aesPlla® is indicated for:

 

  • Volume loss correction in cheeks, temples, jawline, and chin
  • Nasolabial folds and marionette lines
  • Skin laxity improvement in the face, neck, and décolleté
  • Non-surgical facial contouring
  • Bioregenerative protocols for anti-aging prevention

Safety & Considerations

aesPlla® is designed with high purity PLLA microparticles, ensuring gradual resorption and a favorable safety profile. As with other collagen biostimulators, common side effects may include transient redness, swelling, or bruising at the injection sites.

Proper injection technique and patient selection are critical to achieving optimal results and minimizing risks such as nodule formation.


Why Choose aesPlla®?

  • Innovative, regenerative aesthetic approach
  • Stimulates the skin’s natural collagen synthesis
  • Customizable treatment protocols
  • Long-lasting, natural-looking effects
  • Ideal for patients seeking progressive, regenerative rejuvenation without overfilling

 

Conclusion

aesPlla® represents a modern shift in facial aesthetics — moving away from volume-only treatments towards collagen regeneration and skin rejuvenation. Its biostimulatory action, safety profile, and versatility make it a valuable addition to any aesthetic practitioner’s toolkit, particularly for full-face treatments and age-related volume loss management.

As the demand for subtle, regenerative, and long-lasting treatments grows, aesPlla® stands out as a reliable, scientifically backed solution for restoring youthful contours and enhancing skin quality from within.

e-BIOSTIMULATORS Team