Facial aging is a multifactorial process,
characterized by skin laxity, loss of subcutaneous volume, and the gradual
breakdown of collagen and elastin networks. While traditional dermal fillers
address volume loss through mechanical filling, modern aesthetic medicine
increasingly emphasizes regenerative approaches that stimulate the body’s
natural collagen production. Among these, Ellansé has emerged as a pioneering
biostimulator, offering both immediate volumization and long-term tissue
remodeling.
Advanced Technology of Ellansé
Ellansé is a unique dermal filler based on
polycaprolactone (PCL) microspheres suspended in a carboxymethylcellulose (CMC)
gel carrier. Its advanced technology allows for a dual-action effect: immediate
correction through the gel matrix and progressive collagen induction through
the PCL microspheres. Over time, the microspheres biodegrade into natural
byproducts, while stimulating fibroblasts to produce endogenous collagen,
resulting in gradual, natural-looking rejuvenation.
The longevity of Ellansé is determined by the
selection of specific PCL microsphere concentrations, categorized into four
variants (S, M, L, E), offering durations from 1 to 4 years. This adjustable
biodegradation profile allows clinicians to tailor treatments to patient
needs, balancing immediate aesthetic results with sustained tissue remodeling.
Mechanism of Collagen Stimulation
Ellansé’s primary mechanism of action involves the
stimulation of type I and type III collagen through a controlled foreign-body
reaction. Upon injection, PCL microspheres act as a scaffold, attracting
fibroblasts and promoting neocollagenesis. Histological studies have
demonstrated a dense collagen network surrounding the microspheres without
eliciting chronic inflammation, highlighting the safety and efficacy of Ellansé
as a long-term biostimulator.
Advantages of Ellansé in Clinical Practice
The clinical advantages of Ellansé are multifaceted:
1. Immediate
and Long-Term Effects: Patients benefit from immediate
volumization due to the CMC gel, followed by progressive natural collagen
production for sustained results.
2. Customizable
Duration: The availability of multiple PCL formulations allows
practitioners to select the optimal longevity according to patient age, facial
anatomy, and aesthetic goals.
3. Natural
Tissue Integration: Unlike purely volumizing fillers,
Ellansé promotes structural reinforcement of the dermis, restoring elasticity
and contour with minimal risk of unnatural appearance.
4. Predictable
Safety Profile: Extensive clinical trials and post-market
surveillance have confirmed low complication rates and excellent tolerability,
making Ellansé suitable for both new and experienced patients in aesthetic
practice.
Clinical Applications
Ellansé is versatile in facial rejuvenation, suitable
for the correction of:
- Deep nasolabial folds and marionette lines
- Midface volume loss
- Jawline and chin contouring
- Temporal hollowing
Its biostimulatory action also makes it ideal for
patients seeking preventive and early intervention strategies, where collagen
preservation and skin quality improvement are priorities.
Ellansé represents a new generation of
collagen-stimulating dermal fillers, integrating advanced PCL technology with
the advantages of customizable longevity and dual-action effects. Its ability
to combine immediate aesthetic improvement with long-term collagen induction
makes it a valuable tool for clinicians aiming for natural, sustainable facial
rejuvenation. As the demand for regenerative aesthetics grows, Ellansé
exemplifies the shift from traditional volumization toward treatments that
enhance the skin’s intrinsic capacity for renewal and resilience.