Introduction
Preventive
aesthetics has become a rapidly growing field within aesthetic medicine, as
younger patients increasingly seek subtle, non-invasive interventions to delay
visible signs of aging. Among the available options, collagen-based
biostimulators, such as Poly-L-lactic acid (PLLA) and Calcium Hydroxylapatite
(CaHA), offer long-term dermal regeneration by stimulating neocollagenesis
rather than simply filling lines or wrinkles. This case study presents the
treatment of a 29-year-old female with early signs of skin aging using a
collagen biostimulator as part of a preventive anti-aging approach.
Patient Profile and Initial Assessment
The
patient, a healthy 29-year-old female with Fitzpatrick skin type II, presented
with concerns about emerging fine lines on the nasolabial area, slight midface
volume loss, and dullness of complexion. There was no history of cosmetic
treatments or chronic skin conditions. Her main goal was to maintain youthful
skin and support long-term dermal quality without altering her natural facial
features.
A clinical
examination revealed minimal perioral and periorbital rhytids, mild
infraorbital hollowing, and decreased skin elasticity—common markers of early
intrinsic aging.
Treatment Protocol
After
evaluating treatment options, the chosen protocol involved a series of
injections using a collagen biostimulator—specifically Poly-L-lactic
acid (PLLA)—due to its strong neocollagenesis-inducing properties and
long-term preventive effects.
Injection details:
- Product used: Poly-L-lactic acid
(reconstituted 24 hours prior)
- Injection sites: Lateral cheeks, nasolabial
fold areas, and zygomatic zone
- Technique: Deep dermal or subdermal
linear threading and fanning technique using a 25G cannula
- Volume
per session: 1 vial/session
- Frequency: Three sessions spaced four
weeks apart
Post-treatment
care included facial massage instructions (five minutes, five times daily for
five days) to ensure even product distribution and reduce nodule risk.
Clinical Outcomes
Timepoints
evaluated:
Baseline, 8 weeks post-final session, and 6-month follow-up.
By week 8
post-treatment, the patient exhibited:
- Noticeable improvement in skin
elasticity and radiance
- Softening
of nasolabial lines
- Increased midface volume with
no overt “filler” look
- High patient satisfaction and
confidence boost
At the
6-month evaluation, results had continued to improve subtly, indicating active
collagen remodeling. No adverse events were reported other than mild swelling
and bruising post-injection, which resolved within 48 hours.
Discussion
This case
illustrates the value of using biostimulatory agents in a preventive context,
particularly among younger patients seeking long-term aesthetic preservation.
PLLA's gradual mechanism of action provides subtle improvements that align with
patients' desire to age gracefully rather than transform dramatically.
Compared to
traditional dermal fillers that add immediate volume, biostimulators offer a
deeper, regenerative benefit by enhancing the skin's underlying matrix. This
aligns with the shift toward skin quality optimization and prejuvenation.
The
decision to treat this patient early contributed to a more natural,
long-lasting improvement without the need for corrective measures in the
future.
These
findings are supported by literature emphasizing the preventive and
regenerative role of PLLA and CaHA in youthful populations, including:
- Recent Advances in Collagen
Biostimulators for Facial Rejuvenation (Directive Publications, 2024)
- A Multi-Layer Approach to Skin
Rejuvenation
(Scientific Editorial, 2023)
Conclusion
Collagen-based
biostimulators can be effectively used for preventive aesthetic strategies
in patients as young as their late twenties. Through minimally invasive
treatment and gradual results, this case demonstrates that early biostimulatory
interventions may play a key role in delaying visible aging, preserving facial
structure, and enhancing long-term skin health.