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Table of Contents

Introduction

Radiesse (and Radiesse+) is a calcium hydroxylapatite (CaHA)‑based dermal filler designed for patients seeking correction of moderate to severe facial wrinkles and volume lossespecially in the nasolabial folds, jawline, and hands. It stands out by stimulating your body’s natural collagen and elastin production, offering both an immediate volumizing effect and long-term regenerative benefits.

 

Product Portfolio Overview

  • Radiesse: A CaHA microsphere gel for facial correction and hand rejuvenation.
  • Radiesse+: Enhanced jawline contouring, includes lidocaine.
  • Diluted/Hyperdiluted Radiesse: Tailored for skin tightening on areas like neck, décolleté, and hands—without adding bulk.

Key Features & Innovation

  1. Dual Mechanism
    • Immediate volume correction via the gel carrier.
    • Sustained biostimulation: CaHA particles act as a scaffold, inducing fibroblast activation—boosting collagen for up to a year and elastin for ~9 months post-injection.
  2. Versatility & Dilution Options
    • Undiluted for volume; hyperdiluted to focus on skin texture and firmness.
    • Clinical series across 50+ patients showed up to 81.6% average skin improvement, with hyperdiluted protocols achieving up to 95% improvements in younger demographic groups. 
  1. Longevity & Satisfaction
    • Results can last up to 18 months, often averaging 12 months in areas like nasolabial folds.
    • High patient satisfaction: after 4 months, 98% of patients were happy, with 93% willing to repeat treatment and 94% able to recommend it.

Clinical Applications & Results

  • Facial Wrinkles & Volume Loss: Smoothes nasolabial and marionette lines, redefines jawline, restores cheek and chin structures.
  • Hand Rejuvenation: Corrects age-related volume depletion in the dorsal hands.
  • Skin Rejuvenation (Face, Neck, Décolleté, Hands): Hyperdiluted injections significantly improved skin firmness, brightness, elasticity, and vascularity across all age groups, with minimal side effects.

Notable Study:

  • 50 patients treated with various dilution protocols (1:2 to 1:6)
  • Over 80% across age brackets reported marked improvements; the youngest group (30–40yrs) saw a 95% improvement in skin thickness and wrinkle reduction.

Why Choose Radiesse

  • Natural look & feel: Immediate correction transitions to natural collagen remodeling.
  • Biocompatible & safe: CaHA microspheres mimic bone/mineral physiology; no need for allergy testing.
  • Highly customizable: Offers undiluted and diluted versions, adapting to volume versus quality targets.
  • Low downtime: Minor swelling/bruising; most patients resume normal life quickly.
  • High patient satisfaction: Most patients report increased attractiveness, confidence, and repeat usage.

Scientific Support & Safety

Radiesse’s effectiveness in stimulating neocollagenesis and neoelastinogenesis has been validated through multiple studies, noting increases in collagen, elastin, vascularization, proteoglycans, and fibroblasts. Safety profiles are favorable, with typical side effects including bruising, swelling, and nodules—rare and generally transient. Serious adverse events are very rare but include vascular occlusion risks seen with dermal fillers.

Conclusion: Radiesse’s Market Position

Radiesse is more than a volumizing filler—it’s a biostimulator that bridges aesthetic results and regenerative science. Unique in its dual-action CaHA platform, it’s suitable for volume restoration and skin rejuvenation alike. With strong scientific backing, flexible formulations, and enduring patient satisfaction, Radiesse is a trusted leader in regenerative facial rejuvenation.